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Secretory Phospholipase A2 (PLA2) Inhibition Assay

Secretory Phospholipases A2 (sPLA2) are a subfamily of Phospholipases A2 enzymes that catalyze the hydrolysis of phospholipids yielding precursors of pro-inflammatory lipid mediators including bioactive eicosanoids and platelet-activating factor (PAF). sPLA2 inhibitors hold an established role in inflammation treatment, since inhibition of sPLA2 in theory would prevent the formation of inflammatory eicosanoids prior to the cyclooxygenase (COX) reaction. Therefore, theoretically, sPLA2 inhibitors eliminate the need for COX inhibitors in anti-inflammatory therapeutics.

Through sPLA2 inhibition investigation we determine the inhibition potential of a material on sPLA2 activity via enzymatic analysis.